Article
Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2021
Madan Bharat, Zhang Baoshan, Xu Kai, Chao Cara W, O'Dell Sijy, Wolfe Jacy R, Chuang Gwo-Yu, Fahad Ahmed S, Geng Hui, Kong Rui, Louder Mark K, Nguyen Thuy Duong, Rawi Reda, Schön Arne, Sheng Zizhang, Nimrania Rajani, Wang Yiran, Zhou Tongqing, Lin Bob C, Doria-Rose Nicole A, Shapiro Lawrence, Kwong Peter D, DeKosky Brandon J
Abstract excerpt
Vaccine-based elicitation of broadly neutralizing antibodies holds great promise for preventing HIV-1 transmission. However, the key biophysical markers of improved antibody recognition remain uncertain in the diverse landscape of potential antibody mutation pathways, and a more complete understanding of anti-HIV-1 fusion peptide (FP) antibody development will accelerate rational vaccine designs. Here we survey...
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