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Article

Heterogeneity-aware integrative regression for ancestry-specific association studies.

Biometrics - 3 Oct 2024

Molstad Aaron J, Cai Yanwei, Reiner Alexander P, Kooperberg Charles, Sun Wei, Hsu Li

Abstract excerpt

Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral groups. These studies require ancestry-specific models for protein expression as a function of SNP genotypes. In order to improve protein expression prediction in ancestral populations historically underrepresented in genomic studies, we...

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PMID: 39432443
DOI: 10.1093/biomtc/ujae109
PMCID: PMC11492996

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