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Article

Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations.

Genome medicine - 26 Aug 2024

Kamp Michelle, Pain Oliver, Lewis Cathryn M, Ramsay Michèle

Abstract excerpt

BACKGROUND: Cardiovascular diseases (CVD) are a major health concern in Africa. Improved identification and treatment of high-risk individuals can reduce adverse health outcomes. Current CVD risk calculators are largely unvalidated in African populations and overlook genetic factors. Polygenic scores (PGS) can enhance risk prediction by measuring genetic susceptibility to CVD, but their effectiveness in...

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Identifiers

PMID: 39187845
DOI: 10.1186/s13073-024-01377-6
PMCID: PMC11346299

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