Article
Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.
Nature genetics - 1 Jun 2023
Kachuri Linda, Mak Angel C Y, Hu Donglei, Eng Celeste, Huntsman Scott, Elhawary Jennifer R, Gupta Namrata, Gabriel Stacey, Xiao Shujie, Keys Kevin L, Oni-Orisan Akinyemi, Rodríguez-Santana José R, LeNoir Michael A, Borrell Luisa N, Zaitlen Noah A, Williams L Keoki, Gignoux Christopher R, Burchard Esteban González, Ziv Elad
Abstract excerpt
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from 2,733 African Americans, Puerto Ricans and Mexican Americans. We found that heritability of gene expression significantly increased with greater proportions of African genetic ancestry and decreased with higher proportions of Indigenous American ancestry, reflecting...
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