Article

A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain

2025-10-29

Abstract excerpt

Small vessel disease (SVD) impacts healthy aging of organs across the body, yet its contributions to adverse brain aging remain poorly defined. Here we show thromboinflammation, a core feature of SVD, as a driver of adverse brain aging. We identify cerebrospinal fluid fibrinogen as a marker of brain thromboinflammation and screen neurovascular biosignatures mediating its impact on synaptic vulnerability along the...

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Literature Corpus work: 356f92fd-f4b7-5c4f-94c7-7822b21eca48
DOI: 10.1101/2025.10.27.684881

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