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Article

Human brain vascular multi-omics elucidates disease-risk associations.

Neuron - 1 Oct 2025

Reid Madigan M, Menon Shreya, Liu Hao, Zhou Haoyue, Hu Zhirui, Frerich Simon, Ding Bella, Oveisgharan Shahram, Zhang Zimo, Nelson Sophia, Apolonio Amanda, Bennett David A, Dichgans Martin, Pollard Katherine S, Corces M Ryan, Yang Andrew C

Abstract excerpt

Cerebrovascular dysfunction underlies many neurological disorders, yet how genetic variants in brain vascular cells drive disease risk remains unknown. We developed MultiVINE-seq to simultaneously profile RNA and chromatin accessibility in vascular, perivascular, and immune cells from 30 human brains. Mapping genome-wide association study (GWAS) data to our multi-omic atlas linked thousands of GWAS disease-risk...

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Alzheimer Disease
Brain
Cerebrovascular Disorders
Focal Adhesion Kinase 2
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

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PMID: 40730185
DOI: 10.1016/j.neuron.2025.07.001
PMCID: PMC12321221

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PTK2B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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