Article
Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Molecular cell - 3 Nov 2022
Song Lele, Yao Xinyi, Li Hangpeng, Peng Bo, Boka Alan P, Liu Yiman, Chen Guochao, Liu Zhenyang, Mathias Kaeli M, Xia Lingbo, Li Qinglan, Mir Mustafa, Li Yuanyuan, Li Haitao, Wan Liling
Abstract excerpt
Growing evidence suggests prevalence of transcriptional condensates on chromatin, yet their mechanisms of formation and functional significance remain largely unclear. In human cancer, a series of mutations in the histone acetylation reader ENL create gain-of-function mutants with increased transcriptional activation ability. Here, we show that these mutations, clustered in ENL's structured acetyl-reading YEATS...
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