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Article

Irisin improves ROS‑induced mitohormesis imbalance in H9c2 cells

15 Oct 2024

Abstract excerpt

Abnormal mitohormesis is a key pathogenic mechanism that induces a variety of cardiac diseases, including cardiac hypertrophy and heart failure. Irisin as a muscle factor serves a cardioprotective role in response to cellular oxidative stress injury. Rat cardiomyocyte cells (H9c2) were treated with 40 µM exogenous H2O2 to establish an oxidative stress model, followed by addition of 75 nM exogenous irisin for...

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PMID: 39422020
DOI: 10.3892/mmr.2024.13364

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