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Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases

7 May 2025

Abstract excerpt

Irisin is a peptide derived from fibronectin type III domain-containing protein 5 (FNDC5) and is primarily produced by muscle fibers under the regulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) during exercise. Irisin has been the subject of extensive research due to its potential as a metabolic regulator and its antioxidant properties. Notably, it has been associated with...

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PMID: 40427436
DOI: 10.3390/antiox14050554

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