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Article

Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation

1 Jan 2021

Abstract excerpt

Hypoxia affects proliferation, differentiation, as well as death of cardiomyocyte, and plays an important role in the development of myocardial ischemia. However, the detailed mechanisms through which hypoxia regulates cardiomyocyte ferroptosis have not been explored. In this study, we revealed that hypoxia suppresses the proliferation, migration, and erastin-induced ferroptosis of H9c2 cells. First, we confirmed...

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PMID: 33746578
DOI: 10.7150/ijms.50804

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