Article

Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS

2022-11-04

Abstract excerpt

<h4>Background: </h4> Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is the major cause of infertility in women with polycystic ovary syndrome (PCOS). Exercise-induced upregulation of irisin is capable of regulating metabolism by reducing OS and inflammation. Exercise has been shown...

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Literature Corpus work: eca5d380-9046-52b4-a044-fdedc9a91aad
DOI: 10.21203/rs.3.rs-2220731/v1

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