Article

Protopine regulates oxidative stress, apoptosis and autophagy in H9C2 cardiomyocytes under hypoxic conditions

2024-01-01

Abstract excerpt

The heart is highly sensitive to oxygen deprivation, and hypoxia can lead to cardiomyocyte damage and subsequent cardiac dysfunction. Protopine Pro), an isoquinoline alkaloid derived from various herbs, exhibits diverse biological activities. However, the protective mechanisms of Pro against hypoxia-induced cardiomyocyte damage are not well understood. In this study, Pro was observed to stimulate cell proliferatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3aa48d2-6fe9-52d3-b4c6-ff1c668c893a
DOI: 10.22514/sv.2024.132

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protopine regulates oxidative stress, apoptosis and autophagy in H9C2 cardiomyocytes under hypoxic conditionsDOI 10.22514/sv.2024.132Read

A Novel Mitophagy Enhancer Protects Cardiomyocytes against Hypoxia/ReoxygenationSemantic proximity Read

Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 in CardiomyocytesSemantic proximity Read

Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signalingSemantic proximity Read

Irisin improves ROS‑induced mitohormesis imbalance in H9c2 cellsSemantic proximity Read

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanismSemantic proximity Read

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cellsSemantic proximity Read

Bioinformatic Analysis of the Protective Effects of Dexmedetomidine and Thrombopoietin against Hypoxia/Reoxygenation-Induced Injury in AC16 CellsSemantic proximity Read

Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylationSemantic proximity Read

Puerarin Alleviates Myocardial Ischemia-Reperfusion Injury by Enhancing FUNDC1-Mediated MitophagySemantic proximity Read

Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytesSemantic proximity Read

Investigating the protective role of the natural hormone melatonin in reducing drug-induced cardiotoxicity in the therapy of chronic diseasesSemantic proximity Read

Protective mitophagy in human hypoxic cardiomyocytes: mechanistic insights into SGLT2 inhibitor Dapagliflozin cardioprotection in ischemic injurySemantic proximity Read