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Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation

19 Jun 2023

Abstract excerpt

BACKGROUND: Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth. However, the underlying mechanism of whether local GHR acts as a control valve to regulate mitochondrial function through mitochondrial biogenesis during myoblast...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 37337300
DOI: 10.1186/s12964-023-01166-5

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