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Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome

27 Mar 2023

Abstract excerpt

Neuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from spontaneous regression to fatal disease. When these different tumors originate and how they evolve are not known. Here we quantify the somatic evolution of neuroblastoma by deep whole-genome sequencing, molecular clock analysis and population-genetic modeling in a comprehensive cohort covering all subtypes. We find that...

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PMID: 36973454
DOI: 10.1038/s41588-023-01332-y

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