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Article

Myeloid Cell-Specific Deletion of AMPKα1 Worsens Ocular Bacterial Infection by Skewing Macrophage Phenotypes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2024

Singh Sukhvinder, Singh Pawan Kumar, Ahmad Zeeshan, Das Susmita, Foretz Marc, Viollet Benoit, Giri Shailendra, Kumar Ashok

Abstract excerpt

AMP-activated protein kinase (AMPK) plays a crucial role in governing essential cellular functions such as growth, proliferation, and survival. Previously, we observed increased vulnerability to bacterial (Staphylococcus aureus) endophthalmitis in global AMPKα1 knockout mice. In this study, we investigated the specific involvement of AMPKα1 in myeloid cells using LysMCre;AMPKα1fl mice. Our findings revealed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39413004
DOI: 10.4049/jimmunol.2400282
PMCID: PMC11573643

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