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Host AMPK Is a Modulator of Plasmodium Liver Infection

30 Aug 2016

Abstract excerpt

Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here, we demonstrate that the opposite is observed in cells infected with rodent malaria parasites....

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PMID: 27568570
DOI: 10.1016/j.celrep.2016.08.001

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