Article
α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.
Cardiovascular research - 1 Dec 2018
Jansen Thomas, Kröller-Schön Swenja, Schönfelder Tanja, Foretz Marc, Viollet Benoit, Daiber Andreas, Oelze Matthias, Brandt Moritz, Steven Sebastian, Kvandová Miroslava, Kalinovic Sanela, Lagrange Jeremy, Keaney John F, Münzel Thomas, Wenzel Philip, Schulz Eberhard
Abstract excerpt
Aims: Immune cell function involves energy-dependent processes including growth, proliferation, and cytokine production. Since the AMP-activated protein kinase (AMPK) is a crucial regulator of intracellular energy homeostasis, its expression and activity may also affect innate and adaptive immune cell responses. Therefore, we aimed to investigate the consequences of α1AMPK deletion in myelomonocytic cells on...
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