Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

1 Mar 2019

Abstract excerpt

TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabolic modulator 5'-AMP-activated protein kinase (AMPK) and its negative regulator Folliculin (FLCN) act upstream of TFEB/TFE3 in the innate immune response, independently of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Genomics, phytochemicals, and oxidative stress
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30917316
DOI: 10.1016/j.celrep.2019.02.102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen ResistancePMID 30917316Read ↗

Folliculin regulates ampk-dependent autophagy and metabolic stress survival.Semantic proximity Read ↗

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation SurvivalSemantic proximity Read ↗

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling PathwaysSemantic proximity Read ↗

Investigating the contribution of AMPK regulation to physiology and lifespan in C. elegansSemantic proximity Read ↗

Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.Semantic proximity Read ↗

Pharmacologic AMPK Activation Extends Lifespan in <i>C. elegans</i> and Improves Aspects of Healthspan in MiceSemantic proximity Read ↗

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluiditySemantic proximity Read ↗

Developmental plasticity and the response to nutrient stress in Caenorhabditis elegansSemantic proximity Read ↗

AMPK-FOXO-IP3R signaling pathway mediates neurological and developmental defects caused by mitochondrial DNA mutations.Semantic proximity Read ↗

AMPK modulates a DEAH Box RNA-helicase to attenuate TOR signaling and establish developmental quiescenceSemantic proximity Read ↗

AMPK tunes reproductive gene expression and small RNA homeostasis to mediate timely germ cell development.Semantic proximity Read ↗

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.