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Article

AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.

Cell metabolism - 6 Aug 2013

Mounier Rémi, Théret Marine, Arnold Ludovic, Cuvellier Sylvain, Bultot Laurent, Göransson Olga, Sanz Nieves, Ferry Arnaud, Sakamoto Kei, Foretz Marc, Viollet Benoit, Chazaud Bénédicte

Abstract excerpt

Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPKα1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPKα1(-/-) mice. In vivo loss-of-function (LysM-Cre;AMPKα1(fl/fl) mouse) and...

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Identifiers

PMID: 23931756
DOI: 10.1016/j.cmet.2013.06.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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