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Article

Corticosterone Enhances the AMPK-Mediated Immunosuppressive Phenotype of Testicular Macrophages During Uropathogenic Escherichia coli Induced Orchitis.

Frontiers in immunology - 1 Jan 2020

Zhang Zhengguo, Jiang Ziming, Zhang Yiming, Zhang Yu, Yan Yan, Bhushan Sudhanshu, Meinhardt Andreas, Qin Zhihai, Wang Ming

Abstract excerpt

Testicular macrophages (TM) play a central role in maintaining testicular immune privilege and protecting spermatogenesis. Recent studies showed that their immunosuppressive properties are maintained by corticosterone in the testicular interstitial fluid, but the underlying molecular mechanisms are unknown. In this study, we treated mouse bone marrow-derived macrophages (BMDM) with corticosterone (50 ng/ml) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33363533
DOI: 10.3389/fimmu.2020.583276
PMCID: PMC7752858

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