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Article

ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity

1 Oct 2024

Abstract excerpt

This study explores a non-kinase effect of extracellular regulated kinases 1/2 (ERK1/2) on the interaction between deoxyhypusine synthase (DHPS) and its substrate, eukaryotic translation initiation factor 5A (eIF5A). We report that Raf/MEK/ERK activation decreases the DHPS-ERK1/2 interaction while increasing DHPS-eIF5A association in cells. We determined the cryoelectron microscopy (cryo-EM) structure of the...

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PMID: 39392755
DOI: 10.1016/j.celrep.2024.114831

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