Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae.

The Journal of biological chemistry - 16 Jan 1998

Park M H, Joe Y A, Kang K R

Abstract excerpt

Deoxyhypusine synthase catalyzes the first step in the posttranslational synthesis of an unusual amino acid, hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine), in the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein. The null mutation in the single copy gene, yDHS, encodin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Substitution
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Cell Survival

Share to Mutagenesis, Site-Directed

Share to Polymerase Chain Reaction

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 9430712
DOI: 10.1074/jbc.273.3.1677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9430712-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae.PMID 9430712Read ↗

Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.Semantic proximity Read ↗

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.Semantic proximity Read ↗

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.Semantic proximity Read ↗

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved.Semantic proximity Read ↗

ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activitySemantic proximity Read ↗

Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.Semantic proximity Read ↗

The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.Semantic proximity Read ↗

Identification and Characterization of a Novel Deoxyhypusine Synthase in Leishmania donovaniSemantic proximity Read ↗

Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression.Semantic proximity Read ↗

Hypusine-containing protein eIF5A promotes translation elongation.Semantic proximity Read ↗

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.