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Article

Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.

Science signaling - 25 Oct 2011

Carlson Scott M, Chouinard Candace R, Labadorf Adam, Lam Carol J, Schmelzle Katrin, Fraenkel Ernest, White Forest M

Abstract excerpt

The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a wide range of biological processes. Although MAPKs have been intensely studied, identification of their substrates remains challenging. We have optimized a chemical genetic system using analog-sensitive ERK2, a form of ERK2 engineered to use an analog of...

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Identifiers

PMID: 22028470
DOI: 10.1126/scisignal.2002010
PMCID: PMC3779841

Genes

ETV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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