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Article

Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.

Cell metabolism - 7 Sept 2021

Anderson-Baucum Emily, Piñeros Annie R, Kulkarni Abhishek, Webb-Robertson Bobbie-Jo, Maier Bernhard, Anderson Ryan M, Wu Wenting, Tersey Sarah A, Mastracci Teresa L, Casimiro Isabel, Scheuner Donalyn, Metz Thomas O, Nakayasu Ernesto S, Evans-Molina Carmella, Mirmira Raghavendra G

Abstract excerpt

The metabolic inflammation (meta-inflammation) of obesity is characterized by proinflammatory macrophage infiltration into adipose tissue. Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. Hypusinated eIF5A (eIF5AHyp) controls the translation of mRNAs involved in inflammation, but its role in meta-inflammation has not been elucidated. Levels of...

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Identifiers

PMID: 34496231
DOI: 10.1016/j.cmet.2021.08.003
PMCID: PMC8432737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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