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Article

eIF5A-Independent Role of DHPS in p21CIP1 and Cell Fate Regulation.

International journal of molecular sciences - 7 Dec 2021

Becker Andrew E, Wu Pui-Kei, Park Jong-In

Abstract excerpt

Deoxyhypusine synthase (DHPS) catalyzes the first step of hypusination of the elongation translation factor 5A (eIF5A), and these two proteins have an exclusive enzyme-substrate relationship. Here we demonstrate that DHPS has a role independent of eIF5A hypusination in A375 and SK-MEL-28 human melanoma cells, in which the extracellular signal regulated kinase 1/2 (ERK1/2) pathway is deregulated. We found that RNA...

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Identifiers

PMID: 34947982
DOI: 10.3390/ijms222413187
PMCID: PMC8707118

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eIF5A-Independent Role of DHPS in p21CIP1 and Cell Fate Regulation.PMID 34947982Read ↗

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Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.Semantic proximity Read ↗

p21CIP1 Is Dispensable for the G2 Arrest Caused by Genistein in Human Melanoma CellsSemantic proximity Read ↗

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