Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury

9 Nov 2020

Abstract excerpt

CDK5RAP3 was regarded as the most significant regulator of cellular responses against heat stress, which is associated with dysfunctions of the immune system and animal susceptibility to disease. Despite this, little known about how CDK5RAP3 regulates heat stress response. In this study, CDK5RAP3 conditional Knockout (CKO) mice, CDK5RAP3-/- mouse embryo fibroblasts (MEFs) and bovine mammary epithelial cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heat shock proteins research
Share to Thermoregulation and physiological responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33182370
DOI: 10.3390/ijms21218400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat InjuryPMID 33182370Read ↗

Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevitySemantic proximity Read ↗

Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and DiseaseSemantic proximity Read ↗

Potential roles for mitochondria-to-HSF1 signaling in health and diseaseSemantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replicationSemantic proximity Read ↗

Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylationSemantic proximity Read ↗

The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2Semantic proximity Read ↗

Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in RatSemantic proximity Read ↗

Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell LinesSemantic proximity Read ↗

Heat Shock Proteins Promote Cancer: It's a Protection Racket.Semantic proximity Read ↗

Meta-analysis of heat-stressed transcriptomes using the public gene expression database from human and mouse samplesSemantic proximity Read ↗

Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.