Article

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

2026-01-19

Abstract excerpt

The RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) pathway relays extracellular signals into a cellular response and its dysregulation leads to many pathologies, particularly cancer. Here, we determined cryo-EM structures of the MAP2K MEK1 activating its substrate MAPK ERK2, the final event in the cascade. We define the molecular details of specificity and phosphoryl transfer to the tyrosine of the ERK2 a...

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Literature Corpus work: c2da17b0-a1ef-582f-9db1-4c0af0c55369
DOI: 10.64898/2026.01.19.700303

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