Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemia

8 Oct 2024

Abstract excerpt

BACKGROUND: Quiescent self-renewal of leukemia stem cells (LSCs) and resistance to conventional chemotherapy are the main factors leading to relapse of acute myeloid leukemia (AML). Alpha-enolase (ENO1), a key glycolytic enzyme, has been shown to regulate embryonic stem cell differentiation and promote self-renewal and malignant phenotypes in various cancer stem cells. Here, we sought to test whether and how ENO1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Planarian Biology and Electrostimulation
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39380054
DOI: 10.1186/s13287-024-03969-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemiaPMID 39380054Read ↗

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemiaSemantic proximity Read ↗

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomicsSemantic proximity Read ↗

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid LeukemiaSemantic proximity Read ↗

Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencingSemantic proximity Read ↗

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemiaSemantic proximity Read ↗

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemiaSemantic proximity Read ↗

Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewalSemantic proximity Read ↗

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.Semantic proximity Read ↗

Characterization of The Heterogeneity of Bone Marrow in NK-AML (M4/M5) Based on Single Cell RNA SequencingSemantic proximity Read ↗

Machine Learning and Integrative Analysis Reveals Stemness Index-associated Signature in Acute Myeloid LeukemiaSemantic proximity Read ↗

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemiaSemantic proximity Read ↗

Distinct gene regulatory networks govern hematopoietic and leukemia stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.