Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia

3 May 2019

Abstract excerpt

Abstract Molecular genetic changes in acute myeloid leukemia (AML) play crucial roles in leukemogenesis, including recurrent chromosome translocations, epigenetic/spliceosome mutations and transcription factor aberrations. Six1, a transcription factor of the Sine oculis homeobox (Six) family, has been shown to transform normal hematopoietic progenitors into leukemia in cooperation with Eya. However, the specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31050834
DOI: 10.1111/cas.14033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemiaPMID 31050834Read ↗

SIX1 amplification modulates stemness and tumorigenesis in breast cancerSemantic proximity Read ↗

Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemiaSemantic proximity Read ↗

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transitionSemantic proximity Read ↗

Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.Semantic proximity Read ↗

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES proteinSemantic proximity Read ↗

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic programSemantic proximity Read ↗

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemiaSemantic proximity Read ↗

PHF6 suppresses self-renewal of leukemic stem cells in AMLSemantic proximity Read ↗

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid LeukemiaSemantic proximity Read ↗

Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewalSemantic proximity Read ↗

Expression And Clinical Significance of Transcription Factor GRHL1 In Acute Myeloid LeukemiaSemantic proximity Read ↗

Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.