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Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

8 Mar 2023

Abstract excerpt

Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs) that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs to early therapy resistance and AML regeneration remains controversial. We prospectively identify LSCs in AML patients and xenografts by single-cell RNA sequencing coupled with functional validation by a microRNA-126 reporter...

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PMID: 36890137
DOI: 10.1038/s41467-023-36969-0

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