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Article

Optimized periphery-core interface increases fitness of the Bacillus subtilis glmS ribozyme.

Nucleic acids research - 27 Nov 2024

Yu Li-Eng D, White Elise N, Woodson Sarah A

Abstract excerpt

Like other functional RNAs, ribozymes encode a conserved catalytic center supported by peripheral domains that vary among ribozyme sub-families. To understand how core-periphery interactions contribute to ribozyme fitness, we compared the cleavage kinetics of all single base substitutions at 152 sites across the Bacillus subtilis glmS ribozyme by high-throughput sequencing (k-seq). The in vitro activity map...

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Identifiers

PMID: 39319588
DOI: 10.1093/nar/gkae830
PMCID: PMC11602151

Genes

IL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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