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Article

Global fitness landscapes of the Shine-Dalgarno sequence.

Genome research - 1 May 2020

Kuo Syue-Ting, Jahn Ruey-Lin, Cheng Yuan-Ju, Chen Yi-Lan, Lee Yun-Ju, Hollfelder Florian, Wen Jin-Der, Chou Hsin-Hung David

Abstract excerpt

Shine-Dalgarno sequences (SD) in prokaryotic mRNA facilitate protein translation by pairing with rRNA in ribosomes. Although conventionally defined as AG-rich motifs, recent genomic surveys reveal great sequence diversity, questioning how SD functions. Here, we determined the molecular fitness (i.e., translation efficiency) of 49 synthetic 9-nt SD genotypes in three distinct mRNA contexts in Escherichia coli We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424071
DOI: 10.1101/gr.260182.119
PMCID: PMC7263185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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