Article

Accurate inference of the full base-pairing structure of RNA by deep mutational scanning and covariation-induced deviation of activity

2019-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Despite the transcription of noncoding RNAs in 75% of the human genome and their roles in many diseases include cancer, we know very little about them due to lack of structural clues. The centerpiece of the structural clues is the full RNA base-pairing structure of secondary and tertiary contacts that can be precisely obtained only from costly and inefficient 3D structure determination. Here, we...

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Literature Corpus work: 15c06475-2b0a-5eb0-9422-a8e19b91c531
DOI: 10.1101/677310

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