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Article

Fitness landscape of a dynamic RNA structure.

PLoS genetics - 1 Feb 2021

Soo Valerie W C, Swadling Jacob B, Faure Andre J, Warnecke Tobias

Abstract excerpt

RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should capture mutational effects across multiple conformational states simultaneously. Here, we provide a proof-of-principle that this is indeed the case, using the...

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Identifiers

PMID: 33524037
DOI: 10.1371/journal.pgen.1009353
PMCID: PMC7877785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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