Article
Accurate inference of the full base-pairing structure of RNA by deep mutational scanning and covariation-induced deviation of activity.
Nucleic acids research - 20 Feb 2020
Zhang Zhe, Xiong Peng, Zhang Tongchuan, Wang Junfeng, Zhan Jian, Zhou Yaoqi
Abstract excerpt
Despite the large number of noncoding RNAs in human genome and their roles in many diseases include cancer, we know very little about them due to lack of structural clues. The centerpiece of the structural clues is the full RNA base-pairing structure of secondary and tertiary contacts that can be precisely obtained only from costly and time-consuming 3D structure determination. Here, we performed deep mutational...
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