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Article

Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme.

ACS chemical biology - 15 Dec 2017

Dhamodharan V, Kobori Shungo, Yokobayashi Yohei

Abstract excerpt

Deoxyribozymes are catalytic DNA sequences whose atomic structures are generally difficult to elucidate. Mutational analysis remains a principal approach for understanding and engineering deoxyribozymes with diverse catalytic activities. However, laborious preparation and biochemical characterization of individual sequences severely limit the number of mutants that can be studied biochemically. Here, we applied...

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Identifiers

PMID: 29058875
DOI: 10.1021/acschembio.7b00621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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