Article
Addressing the challenges of polygenic scores in human genetic research.
American journal of human genetics - 1 Dec 2022
Novembre John, Stein Catherine, Asgari Samira, Gonzaga-Jauregui Claudia, Landstrom Andrew, Lemke Amy, Li Jun, Mighton Chloe, Taylor Matthew, Tishkoff Sarah
Abstract excerpt
The genotyping of millions of human samples has made it possible to evaluate variants across the human genome for their possible association with risks for numerous diseases and other traits by using genome-wide association studies (GWASs). The associations between phenotype and genotype found in GWASs make possible the construction of polygenic scores (PGSs), which aim to predict a trait or disease outcome in an...
Topics
- Humans
- Multifactorial Inheritance
- Genome-Wide Association Study
- Genetic Research
- Genotype
- Phenotype