Article
Implementation and implications for polygenic risk scores in healthcare.
Human genomics - 20 Jul 2021
Slunecka John L, van der Zee Matthijs D, Beck Jeffrey J, Johnson Brandon N, Finnicum Casey T, Pool René, Hottenga Jouke-Jan, de Geus Eco J C, Ehli Erik A
Abstract excerpt
Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWASs), are able to stratify individuals based on their genetic risk of developing various common diseases and could potentially be used to optimize the use of screening and preventative treatments and improve...
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