Article

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

2024-02-27

Abstract excerpt

<title>Abstract</title> <p>The engineered TadA variants used in cytosine base editors (CBEs) present unique advantages, including a smaller size and fewer off-target effects compared to cytosine base editors that rely on natural deaminases. However, the current TadA variants demonstrate a preference for base editing in DNA with specific motif sequences and possess dual deaminase activity, acting on both cytosine...

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Literature Corpus work: 1f3fed4f-84cf-5ff7-a0be-7e32059168e6
DOI: 10.21203/rs.3.rs-3876111/v1

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