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Metabolic rewiring during bone development underlies tRNA m7G–associated primordial dwarfism

10 Sept 2024

Abstract excerpt

Translation of mRNA to protein is tightly regulated by transfer RNAs (tRNAs), which are subject to various chemical modifications that maintain structure, stability, and function. Deficiency of tRNA N7-methylguanosine (m7G) modification in patients causes a type of primordial dwarfism, but the underlying mechanism remains unknown. Here we report that the loss of m7G rewires cellular metabolism, leading to the...

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PMID: 39255038
DOI: 10.1172/jci177220

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