Article

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

2025-05-19

Abstract excerpt

<h4>Summary</h4> Efficient energy metabolism is essential for health and its dysregulation drives cardiometabolic disease. Delivery of regulatory control through translation and ribosome function is emerging as important. Here, we identify the rRNA methyltransferase BUD23 as a potent regulator of cellular and systemic energy homeostasis. Adipocyte-specific deletion of BUD23 in mice regulates lipid and mitochondri...

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Literature Corpus work: 6aeba2a8-f61f-5b1d-a593-ac3060d7aee0
DOI: 10.1101/2025.05.16.654455

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