Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.

Nature reviews. Genetics - 1 Feb 2015

Kirchner Sebastian, Ignatova Zoya

Abstract excerpt

tRNAs, nexus molecules between mRNAs and proteins, have a central role in translation. Recent discoveries have revealed unprecedented complexity of tRNA biosynthesis, modification patterns, regulation and function. In this Review, we present emerging concepts regarding how tRNA abundance is dynamically regulated and how tRNAs (and their nucleolytic fragments) are centrally involved in stress signalling and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Genetic Diseases, Inborn
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Protein Biosynthesis

Share to RNA, Transfer

Share to Signal Transduction

Share to Stress, Physiological

Source

Identifiers

PMID: 25534324
DOI: 10.1038/nrg3861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.PMID 25534324Read ↗

Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases.Semantic proximity Read ↗

tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human diseaseSemantic proximity Read ↗

Ushering in the era of tRNA medicines.Semantic proximity Read ↗

Charging the code — tRNA modification complexesSemantic proximity Read ↗

Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies.Semantic proximity Read ↗

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read ↗

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors.Semantic proximity Read ↗

The expanding world of tRNA modifications and their disease relevanceSemantic proximity Read ↗

Human mitochondrial tRNA quality control in health and disease: a channelling mechanism?Semantic proximity Read ↗

Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavageSemantic proximity Read ↗

Matching tRNA modifications in humans to their known and predicted enzymesSemantic proximity Read ↗

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.