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Article

A novel cause for primordial dwarfism revealed: defective tRNA modification.

Genome biology - 1 Oct 2015

Filonava Liudmila, Torres Adrian Gabriel, Ribas de Pouplana Lluis

Abstract excerpt

A mutation in the WDR4 gene, coding for a tRNA-modifying enzyme, leads to reduced levels of guanosine methylation in tRNA in patients with primordial dwarfism.

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Topics

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Share to Dwarfism, Pituitary
Share to Methylation
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Share to RNA Processing, Post-Transcriptional

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26429597
DOI: 10.1186/s13059-015-0786-y
PMCID: PMC4591068

Genes

WDR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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