Article

METTL1 mediated tRNA m 7 G modification promotes leukaemogenesis of AML via tRNA regulated translational control

2023-08-01

Abstract excerpt

<h4>Background: </h4> RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m 7 G) modification and its modifiers METTL1/WDR4 have been confirmed an oncogene role in multiple cancers. However, the functions and molecular mechanisms of METTL1/WDR4 in Acute Myeloid Leukemia (AML) remain to be determined. Methods METTL1/WDR4 exp...

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Literature Corpus work: 62a2469c-ebb0-5f5c-97c4-b40a4eaede61
DOI: 10.21203/rs.3.rs-3205496/v1

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