Article
Deficient mitochondrial tRNA modifications arising from TRMU mutation led to the liver-specific failure.
The Journal of biological chemistry - 1 Apr 2026
He Xiao, Zhang Qinghai, Chen Chao, Wu Yutao, Wang Kai, Yao Shihao, Sun Haiyan, Guan Min-Xin
Abstract excerpt
Posttranscriptional nucleotide modifications of tRNAs play the critical roles in their structure and function. Deficient τm5s2U modifications of mitochondrial tRNAGlu, tRNAGln and tRNALys arising from TRMU mutations primarily manifest the liver failure. However, mechanisms of tissue specificity in TRMU-induced deficiencies remain largely elusive. In this report, we demonstrated that the loss of τm5s2U in...
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