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Article

Cohesin mutations in acute myeloid leukemia.

Leukemia - 1 Nov 2024

Boucher Austin, Murray Josiah, Rao Sridhar

Abstract excerpt

The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical regulator of DNA-looping and gene expression. Over a decade has passed since recurrent mutations affecting cohesin subunits were first identified in myeloid malignancies such as Acute Myeloid Leukemia (AML). Since that time there has been tremendous progress in our understanding of chromatin structure and cohesin biology, but critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39251741
DOI: 10.1038/s41375-024-02406-4
PMCID: PMC12284909

Genes

RAD21
SMC1A
SMC3
STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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