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Article

Cohesin in haematopoiesis and leukaemia.

Current opinion in hematology - 1 Jul 2018

Galeev Roman, Larsson Jonas

Abstract excerpt

PURPOSE OF REVIEW: Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin has become...

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Identifiers

PMID: 29697484
DOI: 10.1097/MOH.0000000000000431

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