Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cohesin mutations in myeloid malignancies.

Blood - 26 Aug 2021

Jann Johann-Christoph, Tothova Zuzana

Abstract excerpt

Cohesin is a multisubunit protein complex that forms a ring-like structure around DNA. It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major role in dynamically shaping the genome architecture and maintaining DNA integrity. The core complex subunits STAG2, RAD21, SMC1, and SMC3, as well as its modulators PDS5A/B, WAPL, and NIPBL,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cells
Share to Gene Expression Regulation, Leukemic
Share to Hematologic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Cohesins

Share to Epigenesis, Genetic

Share to Leukemia, Myeloid

Share to Myeloproliferative Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 34157074
DOI: 10.1182/blood.2019004259
PMCID: PMC8394903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cohesin mutations in myeloid malignancies.PMID 34157074Read ↗

Cohesin Mutations in Myeloid Malignancies.Semantic proximity Read ↗

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read ↗

Genetic alterations of the cohesin complex genes in myeloid malignancies.Semantic proximity Read ↗

Cohesin gene mutations in tumorigenesis: from discovery to clinical significance.Semantic proximity Read ↗

Untangling the loops of STAG2 mutations in myelodysplastic syndrome.Semantic proximity Read ↗

Cohesin mutations in acute myeloid leukemia.Semantic proximity Read ↗

Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemiaSemantic proximity Read ↗

Cohesin Mutations in Cancer.Semantic proximity Read ↗

Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes.Semantic proximity Read ↗

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.Semantic proximity Read ↗

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasmsSemantic proximity Read ↗

Cohesin mutations in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.