Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

doi:10.1038/ng.2731

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Article

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Nature genetics - 1 Oct 2013

Kon Ayana, Shih Lee-Yung, Minamino Masashi, Sanada Masashi, Shiraishi Yuichi, Nagata Yasunobu, Yoshida Kenichi, Okuno Yusuke, Bando Masashige, Nakato Ryuichiro, Ishikawa Shumpei, Sato-Otsubo Aiko, Nagae Genta, Nishimoto Aiko, Haferlach Claudia, Nowak Daniel, Sato Yusuke, Alpermann Tamara, Nagasaki Masao, Shimamura Teppei, Tanaka Hiroko, Chiba Kenichi, Yamamoto Ryo, Yamaguchi Tomoyuki, Otsu Makoto, Obara Naoshi, Sakata-Yanagimoto Mamiko, Nakamaki Tsuyoshi, Ishiyama Ken, Nolte Florian, Hofmann Wolf-Karsten, Miyawaki Shuichi, Chiba Shigeru, Mori Hiraku, Nakauchi Hiromitsu, Koeffler H Phillip, Aburatani Hiroyuki, Haferlach Torsten, Shirahige Katsuhiko, Miyano Satoru, Ogawa Seishi

Abstract excerpt

Cohesin is a multimeric protein complex that is involved in the cohesion of sister chromatids, post-replicative DNA repair and transcriptional regulation. Here we report recurrent mutations and deletions involving multiple components of the cohesin complex, including STAG2, RAD21, SMC1A and SMC3,...

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Identifiers

PMID: 23955599
DOI: 10.1038/ng.2731

Genes

RAD21
STAG2
SMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23955599-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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