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Article

A cohesive look at leukemogenesis: The cohesin complex and other driving mutations in AML.

Neoplasia (New York, N.Y.) - 1 Mar 2021

Heimbruch Katelyn E, Meyer Alison E, Agrawal Puja, Viny Aaron D, Rao Sridhar

Abstract excerpt

Acute myeloid leukemia (AML) affects tens of thousands of patients a year, yet survival rates are as low as 25% in certain populations. This poor survival rate is partially due to the vast genetic diversity of the disease. Rarely do 2 patients with AML have the same mutational profile, which makes the development of targeted therapies particularly challenging. However, a set of recurrent mutations in chromatin...

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Topics

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Share to Chromatin
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Cohesins

Share to Disease Susceptibility

Share to Nucleophosmin

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Source

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Identifiers

PMID: 33621854
DOI: 10.1016/j.neo.2021.01.003
PMCID: PMC7905235

Genes

ASXL1
FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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